Safety and efficacy of radiopharmaceuticals 1987 formatIsbn:Softcover 9789401080163 affecting less than 1 in 18 affecting less than 1 in 2000 persons and it is well known that liver diseases can lead to abnormalities in the nutrient metabolism and to subsequent malnutrition The introduction in recent years of nuclear medicine techniques based on radioactive labelled cells and on monoclonal antibodies has stressed the importance of a well functioning approval system for the clinical trial and use of new radiopharmaceuticals International organisations such as the World Health Organisa tion is also including this into their quality assurance programme from both the radiopharmaceutical and the radiation hygiene point of view